Explore KX-826

How DHT Affects Hair Loss & How 826 Helps

Discover how DHT affects hair follicles and how 826 helps block androgen signaling to support healthier follicles, a longer growth phase, and healthier hair growth.

Product efficacy

KOSHINE’s patented core ingredient, 826, is an androgen receptor antagonist. By competitively inhibiting the binding of dihydrotestosterone (DHT) to androgen receptors in target tissues, it helps block DHT–androgen receptor activity, allowing hair follicle cells to return to a healthier state. It also helps improve sebaceous gland hyperplasia and excessive scalp oil production, thereby supporting oil control, hair-loss prevention, and protection against baldness. Full name of 826: Methylpyridinyl Fluoromethoxybenzonitrile Dimethyloxothiooxoimidazolidine

Mechanism of Action

Research indicates that hair follicles affected by androgenetic alopecia are more sensitive to dihydrotestosterone (DHT). DHT binds to androgen receptors, causing follicle miniaturization, shorter growth cycles, thinner hair, and eventually hair loss. This process is often accompanied by increased scalp oil production. 826 is an androgen receptor antagonist that competitively blocks DHT from binding to androgen receptors, helping reduce androgen-related effects on hair follicles. With consistent use, it may help support healthier follicles, reduce hair loss, extend the growth phase, and promote a healthier hair-growth cycle.

Data Source: KX0826-CN-1002 Phase II Clinical Study Report, Treatment Group II.

Experimental Data

According to the clinical trial report, 826 demonstrated favorable efficacy and safety. In the 0.5% twice-daily (BID) treatment group, the target area’s non-vellus hair count increased by 22.73 hairs/cm² from baseline after 24 weeks of treatment. Some participants observed visible hair regrowth as early as Week 6.

Real Results. Real People.

5.00

“13 Months of Koshine826.Beginning 0.5%Since 9 Months 0.9%Works Great , thank you guys.”

JulianVic98

5.00

“Tried other treatments that made my scalp red and itchy. Koshine’s formula feels clean and calming.”

Victor S

5.00

“Using it twice a day became routine. My scalp feels healthier, and I’ve noticed less hair on my pillow.”

Liam P

5.00

“Combining it with the botanical serum gave better texture and thickness than anything else I’ve tried.”

Paul W

5.00

“My part line looked wider every year — now it’s clearly filling in. Even my stylist noticed the difference”

Emily S

5.00

“My parting doesn’t look empty anymore. The volume around the top feels much fuller now.”

Olivia N

Protected By Patents. Driven By Science.

Explore our collection of patent certificates and related intellectual property documents, reflecting our ongoing commitment to research, innovation, and science-driven hair and scalp care.